@article{ref1,
title="Pretreatment frontal EEG and changes in suicidal ideation during SSRI treatment in major depressive disorder",
journal="Acta psychiatrica Scandinavica",
year="2008",
author="Iosifescu, D. V. and Greenwald, S. and Devlin, P. and Perlis, Roy H. and Denninger, J. W. and Alpert, Jonathan E. and Fava, Maurizio",
volume="117",
number="4",
pages="271-276",
abstract="OBJECTIVE: We investigated frontal quantitative EEG (QEEG) as predictor of changes in suicidal ideation (SI) during SSRI treatment in major depressive disorder (MDD). METHOD: Eighty-two subjects meeting DSM-IV criteria for MDD entered an 8-week, prospective, open-label treatment with flexible dose SSRIs and completed at least 4 weeks of treatment. We assessed MDD severity with the 17-item Hamilton Depression Rating Scale (HAM-D-17); change in SI was measured with HAM-D item no. 3. We recorded four-channel EEGs (F7-Fpz, F8-Fpz, A1-Fpz, A2-Fpz) before treatment. RESULTS: During the first 4 weeks of treatment 9 (11%) subjects experienced worsening SI. Left-right asymmetry of combined theta + alpha power correlated significantly with change in SI from baseline, even when adjusting for changes in depression severity (HAM-D-17) and for the SSRI utilized. CONCLUSION: Frontal QEEG parameters before treatment may predict worsening SI during SSRI treatment in MDD.<p /> <p>Language: en</p>",
language="en",
issn="0001-690X",
doi="10.1111/j.1600-0447.2008.01156.x",
url="http://dx.doi.org/10.1111/j.1600-0447.2008.01156.x"
}