@article{ref1,
title="Altered serotonin 2C receptor RNA splicing in suicide: association with editing",
journal="Neuroreport",
year="2008",
author="Dracheva, S. and Chin, Benjamin and Haroutunian, V.",
volume="19",
number="3",
pages="379-382",
abstract="In an earlier study, we showed increases in serotonin 2C receptor (5-HT2CR) pre-mRNA editing in prefrontal cortex that were specific to suicide victims irrespective of associated psychiatric diagnoses. Here we demonstrate that the ratio between the two 5-HT2CR splice variants is increased in people who committed suicide, but does not vary among the diagnostic groups. This provides further evidence for suicide-specific neurobiology and suggests that, as it was previously shown in vitro, 5-HT2CR editing modulates its splicing in human brain. The association analysis indicates, however, that the efficiency of 5-HT2CR editing is an imperfect predictor of the splicing outcome, and that splice site selection is only partially controlled by the level of editing in vivo.<p /> <p>Language: en</p>",
language="en",
issn="0959-4965",
doi="10.1097/WNR.0b013e3282f556d2",
url="http://dx.doi.org/10.1097/WNR.0b013e3282f556d2"
}