@article{ref1,
title="Childhood adversity, early-onset depressive/anxiety disorders, and adult-onset asthma",
journal="Psychosomatic medicine",
year="2008",
author="Scott, Kate M. and Von Korff, M. and Alonso, Jordi and Angermeyer, Matthias C. and Benjet, Corina and Bruffaerts, Ronny and de Girolamo, Giovanni and Haro, Josep Maria and Kessler, Ronald C. and Kovess, Viviane and Ono, Y. and Ormel, Johan and Posada-Villa, Jose",
volume="70",
number="9",
pages="1035-1043",
abstract="OBJECTIVES: To investigate a) whether childhood adversity predicts adult-onset asthma; b) whether early-onset depressive/anxiety disorders predict adult-onset asthma; and c) whether childhood adversity and early-onset depressive/anxiety disorders predict adult-onset asthma independently of each other. Previous research has suggested, but not established, that childhood adversity may predict adult-onset asthma and, moreover, that the association between mental disorders and asthma may be a function of shared risk factors, such as childhood adversity. METHODS: Ten cross-sectional population surveys of household-residing adults (>18 years, n = 18,303) assessed mental disorders with the Composite International Diagnostic Interview (CIDI 3.0) as part of the World Mental Health surveys. Assessment of a range of childhood family adversities was included. Asthma was ascertained by self-report of lifetime diagnosis and age of diagnosis. Survival analyses calculated hazard ratios (HRs) for risk of adult-onset (>age 20 years) asthma as a function of number and type of childhood adversities and early-onset (<age 21 years) depressive and anxiety disorders, adjusting for current age, sex, country, education, and current smoking. RESULTS: Childhood adversities predicted adult-onset asthma with risk increasing with the number of adversities experienced (HRs = 1.49-1.71). Early-onset depressive and anxiety disorders also predicted adult-onset asthma (HRs = 1.67-2.11). Childhood adversities and early-onset depressive and anxiety disorders both predicted adult-onset asthma after mutual adjustment (HRs = 1.43-1.91). CONCLUSIONS: Childhood adversities and early-onset depressive/anxiety disorders independently predict adult-onset asthma, suggesting that the mental disorder-asthma relationship is not a function of a shared background of childhood adversity.<p /> <p>Language: en</p>",
language="en",
issn="0033-3174",
doi="10.1097/PSY.0b013e318187a2fb",
url="http://dx.doi.org/10.1097/PSY.0b013e318187a2fb"
}