@article{ref1,
title="Emotionally controlled decision-making and a gene variant related to serotonin synthesis in women with borderline personality disorder",
journal="Scandinavian journal of psychology",
year="2009",
author="Maurex, Liselotte and Zaboli, Ghazal and Wiens, Stefan and Åsberg, Marie and Leopardi, Rosario and Ohman, Ann",
volume="50",
number="1",
pages="5-10",
abstract="The Iowa Gambling Task (IGT) was used to examine (i) social decision-making in women with borderline personality disorder (BPD), and (ii) the relationship between impaired decision-making and the tryptophan hydroxylase-1 (TPH-1) gene, involved in serotonin synthesis. Forty-two women with BPD and a history of suicide attempts were genotyped, and the frequency of a TPH-1 haplotype previously uniquely associated with BPD was calculated. The BPD group scored significantly lower than a control group in the IGT. Furthermore, the TPH-1 haplotype displayed a significantly higher frequency in BPD participants with impaired decision making, compared to BPD participants with normal scores. These findings suggest that impaired decision-making as determined by the IGT is a feature of BPD and may be (i) associated with serotonin dysfunction, and (ii) possibly relevant for suicidal behavior.<p /><p>Language: en</p>",
language="en",
issn="0036-5564",
doi="10.1111/j.1467-9450.2008.00689.x",
url="http://dx.doi.org/10.1111/j.1467-9450.2008.00689.x"
}