@article{ref1,
title="Alterations of coagulation in metformin intoxication",
journal="Hormones : international journal of endocrinology and metabolism",
year="2008",
author="Akinci, Baris and Yener, Serkan and Bengi, Goksel and Yesil, Sena",
volume="7",
number="4",
pages="325-329",
abstract="It is widely known that metformin reduces the levels of circulating pro-coagulant factors and improve fibrinolytic activity in type 2 diabetes when used in therapeutic doses. Potential alterations of coagulation have not been reported in patients with metformin intoxication. We evaluated certain components of the coagulation system in a patient with metformin intoxication upon admission and after recovery. Our results indicate that both the levels of coagulation proteins synthesized by the liver and the anti-coagulant activity decrease temporarily in metformin intoxication. Nevertheless, no change in the coagulation factors secreted by the endothelium were observed.<p /> <p>Language: en</p>",
language="en",
issn="1109-3099",
doi="",
url="http://dx.doi.org/"
}