@article{ref1,
title="Reduced orexin levels in the cerebrospinal fluid of suicidal patients with major depressive disorder",
journal="European Neuropsychopharmacology",
year="2007",
author="Brundin, Lena and Björkqvist, Maria and Petersen, Asa and Träskman-Bendz, Lil",
volume="17",
number="9",
pages="573-579",
abstract="Orexins are neuropeptides selectively expressed in a small number of neurons in the lateral-posterior hypothalamus. We measured orexin-A in the cerebrospinal fluid (CSF) of 66 patients with major depressive disorder (MDD), dysthymia and adjustment disorder after a suicide attempt. Blood samples confirmed that the patients were free from antidepressive and neuroleptic medication at the time of the lumbar punctures. CSF levels of orexin-A were significantly lower in patients with MDD than in patients with adjustment disorder and dysthymia. Orexin correlated significantly with CSF levels of somatostatin, delta sleep inducing peptide-like immunoreactivity (DSIP-LI) and corticotrophin releasing factor (CRF), but not with leptin or vasopressin. Plasma levels of thyroid-stimulating hormone (TSH) were not reduced in MDD patients, and did not correlate with CSF-orexin. Our results suggest that suicidal patients with MDD have distinct neurobiological features, involving compromised levels of hypothalamic peptides regulating the state of arousal.<p /> <p>Language: en</p>",
language="en",
issn="0924-977X",
doi="10.1016/j.euroneuro.2007.01.005",
url="http://dx.doi.org/10.1016/j.euroneuro.2007.01.005"
}