@article{ref1,
title="Interaction between MAO-A genotype and maltreatment in the risk for conduct disorder: failure to confirm in adolescent patients",
journal="American journal of psychiatry",
year="2006",
author="Young, Susan E. and Smolen, Andrew and Hewitt, J. K. and Haberstick, Brett C. and Stallings, Michael C. and Corley, Robin P. and Crowley, Thomas J.",
volume="163",
number="6",
pages="1019-1025",
abstract="OBJECTIVE: Childhood maltreatment is a potent risk factor for subsequent aggressive and criminal behavior. A recent study suggested that the relationship between maltreatment and antisocial behavior may be moderated by a genetic vulnerability conferred by a functional polymorphism in the MAO-A gene. The authors investigated whether these findings would generalize to a clinical cohort of adolescents, examining whether there was a stronger association between maltreatment and conduct disorder severity in patients carrying the low MAO-A activity allele. METHOD: Male adolescent patients (N=247) entering residential or intensive day treatment for persistent conduct and substance use problems were examined. Conduct disorder severity was indexed by a lifetime count of DSM-IV criteria obtained through structured psychiatric interviews. Maltreatment scores were derived from summing neglect and abuse events reported to have occurred before age 11. RESULTS: Neglect, verbal/psychological abuse, physical abuse, and sexual abuse were prevalent among patients. Although level of maltreatment and lifetime conduct disorder symptoms were significantly correlated, no genetic-environmental interaction with genotype for maltreatment was found. CONCLUSION: The results of the current study do not support the hypothesis that a polymorphism in the gene encoding MAO-A contributes to the genetic risk for conduct disorder.<p /> <p>Language: en</p>",
language="en",
issn="0002-953X",
doi="10.1176/appi.ajp.163.6.1019",
url="http://dx.doi.org/10.1176/appi.ajp.163.6.1019"
}