@article{ref1,
title="Association study between the novel functional polymorphism of the serotonin transporter gene and suicidal behaviour in schizophrenia",
journal="European Neuropsychopharmacology",
year="2006",
author="De Luca, Vincenzo and Zai, Gwyneth C. and Tharmalingam, Subi and de Bartolomeis, Andrea and Wong, Greg and Kennedy, James L.",
volume="16",
number="4",
pages="268-271",
abstract="A serotonin transporter gene linked polymorphic region (5-HTTLPR) has been investigated in several genetic association studies, including studies of schizophrenia and suicidality. The current study was designed to examine whether the new long (A/G) variant polymorphism of the 5-HTT gene may be associated with suicide attempts of 290 Caucasian schizophrenic patients. Among these patients, 92 had a history of suicide attempt. No association with history of suicide attempt was found in the multiallelic 5-HTTLPR (p = 0.305), however we found significant association with the intron 2 VNTR polymorphism (p = 0.018). When we performed a haplotype analysis, we found association between suicide attempt and haplotype distribution (p = 0.031). These findings suggest that the intron 2 VNTR polymorphism in serotonin transporter gene may influence suicidal behaviour in schizophrenia.<p /> <p>Language: en</p>",
language="en",
issn="0924-977X",
doi="10.1016/j.euroneuro.2005.09.007",
url="http://dx.doi.org/10.1016/j.euroneuro.2005.09.007"
}