@article{ref1,
title="alpha-11CMethyl-L-tryptophan trapping in the orbital and ventral medial prefrontal cortex of suicide attempters",
journal="European Neuropsychopharmacology",
year="2006",
author="Leyton, Marco and Paquette, Vincent and Gravel, Paul and Rosa-Neto, Pedro and Weston, Francine and Diksic, Mirko and Benkelfat, Chawki",
volume="16",
number="3",
pages="220-223",
abstract="Low serotonin neurotransmission is thought to increase vulnerability to suicidal behavior. To test this hypothesis, we measured brain regional serotonin synthesis, as indexed by PET and alpha-(11)Cmethyl-L-tryptophan trapping, in 10 patients who had made a high-lethality suicide attempt and 16 healthy controls. Compared to healthy controls, suicide attempters had reduced normalized alpha-(11)Cmethyl-L-tryptophan trapping in orbital and ventromedial prefrontal cortex. alpha-(11)CMethyl-L-tryptophan trapping in these regions correlated negatively with suicide intent. Low serotonin synthesis in the prefrontal cortex might lower the threshold for suicidal behavior.<p /> <p>Language: en</p>",
language="en",
issn="0924-977X",
doi="10.1016/j.euroneuro.2005.09.006",
url="http://dx.doi.org/10.1016/j.euroneuro.2005.09.006"
}