@article{ref1,
title="Effect of SNP at position 40237 in exon 7 of the TPH2 gene on susceptibility to suicide",
journal="Brain research",
year="2006",
author="Ke, Li and Qi, Zhang Yu and Ping, Yan and Ren, Cheng Yi",
volume="1122",
number="1",
pages="24-26",
abstract="OBJECTIVE: The novel tryptophan hydroxylase isoform (TPH2), being the rate-limiting enzyme in the biosynthesis of serotonin, has many biological functions and plays an important role as candidate gene in several psychiatric disorders. Here, an A-G single nucleotide polymorphism (SNP) at the position 40237 relative to 5'-end of TPH2 gene was selected for the association with suicide behavior. METHODS: The study population consisted of 102 MD patients with suicide behavior as attempters and 123 MD patients without suicide behavior as non-attempters. The TPH2 SNP was determined by sequencing on an ABI 3700 automated DNA sequencer. RESULTS: The A allele was significantly less frequent in attempters than in non-attempters (p=0.0067). Individuals with the A/A genotype showed a significantly lower risk of suicide behavior than those with the A/G or G/G genotype (OR=0.35). CONCLUSIONS: Our findings suggest that the A-G polymorphism of TPH2 may confer susceptibility to suicide behavior in MD patients.<p /> <p>Language: en</p>",
language="en",
issn="0006-8993",
doi="10.1016/j.brainres.2006.09.007",
url="http://dx.doi.org/10.1016/j.brainres.2006.09.007"
}