@article{ref1,
title="Prevalence of herpes simplex virus types 1 and 2 among children and adolescents attending a sexual abuse clinic",
journal="Pediatric infectious disease journal",
year="2006",
author="Ramos, S. and Lukefahr, James L. and Morrow, Rhoda Ashley and Stanberry, Lawrence R. and Rosenthal, Susan L.",
volume="25",
number="10",
pages="902-905",
abstract="BACKGROUND: Children and adolescents with a history of sexual abuse are at risk for acquiring herpes simplex virus (HSV) type 2. We evaluated the prevalence of HSV-1 and HSV-2 and the usefulness for this population of 2 commercially available tests. METHODS: Sera from 150 children seen in a sexual abuse clinic were analyzed for type-specific HSV antibodies using Focus HerpeSelect HSV-2 ELISA (Focus), Biokit HSV-2 Rapid Test (Biokit), and by Western blot (WB). RESULTS: The patient sample was 81% female, had a mean age of 11.6 years (range, 1 to 18 years), and was 46% Caucasian, 28% Hispanic, 25% African American, and 2% other. According to WB, 77 (51%) of the children were HSV-1 seropositive. For HSV-2, there was 1 &quot;true positive&quot; (positive by all 3 tests) and 1 patient whose serum had atypical HSV-2 bands by WB but was positive by Focus. There were 6 sera that were positive by Focus and negative by WB. Index values of these 6 Focus tests were not predictive of WB status. For the 105 samples for which Biokit data were available, all samples were concordant with WB. CONCLUSIONS: The findings of this study suggest that routine screening for HSV-2 in sexually abused children does not have a high yield. The Focus test has an unacceptably high rate of false-positive results in children; however, Biokit may be an acceptable substitute for WB in evaluating children for HSV-2 antibodies.<p /> <p>Language: en</p>",
language="en",
issn="0891-3668",
doi="10.1097/01.inf.0000237831.79072.c8",
url="http://dx.doi.org/10.1097/01.inf.0000237831.79072.c8"
}