@article{ref1,
title="Effect of active metabolites of chlordiazepoxide and diazepam, alone or in combination with alcohol, on psychomotor skills related to driving",
journal="Modern problems in pharmacopsychiatry",
year="1976",
author="Palva, E. S. and Linnoila, M. and Mattila, M. J.",
volume="11",
number="",
pages="79-84",
abstract="The interaction of the main metabolites of diazepam and chlordiazepoxide with alcohol was measured in two double-blind crossover subacute experiments on 40 healthy young volunteers. The drugs were administered for 2 weeks each. The variables measured were choice reaction time and accuracy, eye-hand coordination, divided attention, flicker fusion, proprioception, and nystagmus. ChL, MO and O significantly enhanced the alcohol-induced impairment of psychomotor skills whereas DMD did so only exceptionally on some subjects in the choice reaction test. It is concluded that the diazepam-alcohol interaction on psychomotor skills is mainly due to the parent compound. No correlations between the serum levels of the agents and the changes of performance were found.<p /><p>Language: en</p>",
language="en",
issn="0077-0094",
doi="",
url="http://dx.doi.org/"
}