@article{ref1,
title="The effects of zimeldine and amitriptyline on car driving and psychomotor performance",
journal="Acta psychiatrica Scandinavica. Supplementum",
year="1983",
author="Hindmarch, I. and Subhan, Z. and Stoker, M. J.",
volume="308",
number="",
pages="141-146",
abstract="The development of an objective measure of car driving performance, brake reaction time (BRT), is described, and the effects of amitriptyline and zimeldine on this measure are compared in a placebo-controlled, acute, single dose, volunteer study. The effects of treatment on laboratory tests of critical flicker fusion (CFF) threshold, choice reaction time (CRT) and tracking accuracy and on self-assessments of sedation are also examined. At 2 hours post-treatment, amitriptyline produced a significant increase in brake reaction time when compared to both placebo and zimeldine. At 4 hours post-treatment, a significant reduction in &quot;tracking accuracy&quot; and a significant increase in CRT was observed after treatment with amitriptyline, while no such effects were seen with zimeldine. Measures of CFF threshold and self-ratings of sedation also revealed that amitriptyline produced a significant degree of sedation at 4 hours when compared to zimeldine and placebo. In contrast, zimeldine produced elevated CFF threshold, but did not affect self-ratings of sedation.<p /><p>Language: en</p>",
language="en",
issn="0065-1591",
doi="",
url="http://dx.doi.org/"
}