@article{ref1,
title="5-hydroxytryptamine and depression: a model for the interaction of normal variance with pathology",
journal="British journal of clinical pharmacology",
year="1983",
author="Goodwin, Frederick K. and Post, R. M.",
volume="15",
number="Suppl 3",
pages="393S-405S",
abstract="1 Theories linking 5-hydroxytryptamine (5-HT) with depression are briefly reviewed. The various experimental strategies adopted to investigate this relationship, examination of autopsy data, CSF metabolite data, 5-HT re-uptake patterns in human blood platelets and imipramine binding studies in human platelets, are discussed. 2 Recent studies of 5-hydroxyindole acetic acid (5-HIAA) levels in cerebrospinal fluid have revealed a linkage between low 5-HIAA levels and suicide, aggression and impulsivity. Decreases in the number of imipramine binding sites have also been found in brains of suicide victims. 3 The available data lead to the conclusion that decreased 5-hydroxytryptaminergic function may be associated with an increased risk of depression, suicide, and some types of aggression.<p /> <p>Language: en</p>",
language="en",
issn="0306-5251",
doi="",
url="http://dx.doi.org/"
}