@article{ref1,
title="Naltrexone attenuates self-injurious behavior in mentally retarded subjects",
journal="Biological psychiatry",
year="1990",
author="Kars, H. and Broekema, W. and Glaudemans-van Gelderen, I. and Verhoeven, W. M. and van Ree, J. M.",
volume="27",
number="7",
pages="741-746",
abstract="The effect of naltrexone on the frequency of self-injurious behavior (SIB) was investigated in 6 male subjects with profound mental retardation. Following a double-blind placebo-controlled crossover design, naltrexone was administered in a dose of 50 mg once daily for 3 consecutive weeks. In 2 of 5 subjects, a significant decrease of SIB frequency could be demonstrated, and in 1, a tendency to a reduction was found. No effect on duration of restrain time was found in 3 subjects. These data suggest that disturbances of the endogenous opioid systems may be involved in the pathophysiology of SIB of certain patients.<p /> <p>Language: en</p>",
language="en",
issn="0006-3223",
doi="",
url="http://dx.doi.org/"
}