@article{ref1,
title="Serotonin, suicide, and aggression: clinical studies",
journal="Journal of clinical psychiatry",
year="1991",
author="Golden, Robert N. and Gilmore, J. H. and Corrigan, M. H. and Ekstrom, R. D. and Knight, B. T. and Garbutt, J. C.",
volume="52",
number="Suppl",
pages="61-69",
abstract="Both suicidal and aggressive, impulsive behaviors have been linked to putative dysregulation in central serotonergic systems. We review data examining the role of serotonin (5-HT) in suicide from postmortem studies and clinical investigations of suicide attempters, including our own preliminary work derived from neuroendocrine challenges with the 5-HT uptake inhibitor clomipramine. Various approaches to the study of 5-HT and aggressive, impulsive behavior, including cerebrospinal fluid studies, investigations of peripheral measures of 5-HT, and neuroendocrine studies utilizing 5-HT probes, are highlighted. Several important caveats, including the challenge of quantifying &quot;suicidality&quot; and &quot;aggression&quot; in reliable and valid ways, should be considered in interpreting the results of clinical studies of 5-HT and suicide and aggression.<p /> <p>Language: en</p>",
language="en",
issn="0160-6689",
doi="",
url="http://dx.doi.org/"
}