@article{ref1,
title="Relationship between central and peripheral serotonin indexes in depressed and suicidal psychiatric inpatients",
journal="Archives of general psychiatry",
year="1992",
author="Mann, J. John and McBride, P. A. and Brown, Ryan P. and Linnoila, M. and Leon, Andrew C. and DeMeo, M. and Mieczkowski, Tom and Myers, J. E. and Stanley, M.",
volume="49",
number="6",
pages="442-446",
abstract="Serious suicidal behavior, affective disorders, and a variety of other psychopathologic behaviors and syndromes have been found to correlate with measures of the serotonin system. Clinical studies have employed a range of serotonin indexes, including the cerebrospinal fluid level of 5-hydroxyindoleacetic acid, the prolactin response to serotonin agonists, such as fenfluramine hydrochloride, and platelet serotonin-related proteins or serotonin content. Many of these indexes are correlated with suicidal behavior, but the interrelationship of these biologic measures has been uncertain. We studied the relationship of a series of serotonin indexes in patients in whom these measures were correlated with suicidal behavior. A positive correlation was found between cerebrospinal fluid 5-hydroxyindoleacetic acid and the maximal prolactin response to fenfluramine but not with platelet serotonin2 receptor indexes. The fenfluramine-stimulated maximal prolactin response correlated with platelet serotonin2 receptor number, particularly in older patients. We conclude that cerebrospinal fluid 5-hydroxyindoleacetic acid measurements cannot be replaced but can be complemented by less invasive procedures, such as a fenfluramine challenge test or platelet serotonin2 measures, in the study of the relationship of the serotonin system to psychiatric disorders.<p /> <p>Language: en</p>",
language="en",
issn="0003-990X",
doi="",
url="http://dx.doi.org/"
}