@article{ref1,
title="Alterations in monoamine receptors in the brain of suicide victims",
journal="Journal of clinical psychopharmacology",
year="1992",
author="Arango, V. and Underwood, Mark D. and Mann, J. John",
volume="12",
number="2 Suppl",
pages="8S-12S",
abstract="Suicide has been linked to alterations in the serotonergic and noradrenergic systems. Using in vitro quantitative receptor autoradiography, we compared the binding of 125I-lysergic acid diethylamide (5-hydroxytryptamine-2 sites) and 125I-pindolol (beta-adrenergic sites) with slide-mounted sections from the prefrontal and the temporal cortex of a group of suicide victims, matched to control specimens on postmortem interval, age, sex, and race. A specific laminar distribution of 5-hydroxytryptamine-2 binding was found in both groups, with layers III and IV having the highest level of binding, but beta-adrenergic binding did not differ across cortical layers. Binding to both 125I-lysergic acid diethylamide and 125I-pindolol was increased in the prefrontal cortex of the suicide victims, whereas only beta-adrenergic binding was increased in the temporal cortex of the suicide group.<p /> <p>Language: en</p>",
language="en",
issn="0271-0749",
doi="",
url="http://dx.doi.org/"
}