@article{ref1,
title="NMDA glutamatergic receptors, labelled with 3H.MK-801, in brain samples from drug-free depressed suicides",
journal="Brain research",
year="1993",
author="Holemans, S. and De Paermentier, F. and Horton, R. W. and Crompton, M. R. and Katona, C. L. and Maloteaux, J. M.",
volume="616",
number="1-2",
pages="138-143",
abstract="Glutamate receptors of the NMDA-subtype were quantitated by binding of 3H.dizocilpine maleate (MK-801) in nine brain regions from 22 suicide victims (20-60 yr), with a firm retrospective diagnosis of depression, who had not recently received antidepressant drugs, and 20 age- and sex-matched controls. 3H.MK-801-binding did not differ between suicides and controls in any region studied. Suicides who died violently did not differ from non-violent suicides and controls. A significative negative correlation was found between age and NMDA receptor-binding in the frontal cortex of suicide victims, but not in controls. This preliminary study provides little evidence for an important role of NMDA-binding sites in the pathophysiology of depression.<p /> <p>Language: en</p>",
language="en",
issn="0006-8993",
doi="",
url="http://dx.doi.org/"
}