@article{ref1,
title="Role of the GABA(B) receptor in alcohol-seeking and drinking behavior",
journal="Alcohol",
year="2009",
author="Maccioni, Paola and Colombo, Giancarlo",
volume="43",
number="7",
pages="555-558",
abstract="The present paper summarizes experimental data demonstrating the reducing effect of direct agonists and positive allosteric modulators (PAMs) of the gamma-aminobutyric acid(B) (GABA(B)) receptor on different alcohol-related behaviors. Different lines of evidence indicate that direct agonists, including baclofen, effectively suppress acquisition and maintenance of alcohol drinking behavior, relapse-like drinking, and alcohol's reinforcing, rewarding, stimulating, and motivational properties in rats and mice. More recently, the discovery of a positive allosteric modulatory binding site, together with the synthesis of in vivo effective ligands, opened a new avenue of research in GABA(B) pharmacology. Accumulating lines of evidence suggest that PAMs retain baclofen's capcity to suppress alcohol consumption and alcohol's reinforcing and motivational properties in rats; these effects occur at doses far from those producing behavioral toxicity.<p /> <p>Language: en</p>",
language="en",
issn="0741-8329",
doi="10.1016/j.alcohol.2009.09.030",
url="http://dx.doi.org/10.1016/j.alcohol.2009.09.030"
}