@article{ref1,
title="Electrocardiographic changes in a rare case of flecainide poisoning: a case report",
journal="Cases journal",
year="2009",
author="Rognoni, Andrea and Bertolazzi, Marzia and Peron, Marzia and Macciò, Sergio and Cameroni, Gemma Ternavasio and Gratarola, Angelo and Rognoni, Giorgio",
volume="2",
number="",
pages="9137-9137",
abstract="Flecainide is a class Ic anti-arrhythmic drug with sodium channel blocking activities. We report a case of a 57 year - old woman who attempted a suicide by ingesting approximately 1,8 gr of flecainide. On the surface electrocardiogram this results in a large QRS complex and in prolongation of the QTc interval. Overdose with a class Ic drug is very uncommon, its management is difficult and the mortality high.Because of a hemodynamic instability and in addition to supportive care and antidysrhythmics, she was treated with a high dose of sodium bicarbonate in hypertonic solution; after this infusion the patient's QRS progressive narrowed.In conclusion, sodium bicarbonate may be useful in the treatment of widened QRS and to stabilize a overdose of class Ic anti-arrhythmic drugs.<p /> <p>Language: en</p>",
language="en",
issn="1757-1626",
doi="10.1186/1757-1626-2-9137",
url="http://dx.doi.org/10.1186/1757-1626-2-9137"
}