@article{ref1,
title="The association between admission for poisoning with paracetamol or other weak analgesics and subsequent admission for psychiatric disorder: a Danish nationwide case-control study",
journal="Alimentary pharmacology and therapeutics",
year="2005",
author="Jepsen, Peter and Qin, Ping and Norgard, B. and Agerbo, Esben and Mortensen, P. B. and Vilstrup, H. and Sorensen, H. T.",
volume="22",
number="7",
pages="645-651",
abstract="Summary Background : Many cases of paracetamol poisoning are with suicidal intent, but the association between paracetamol poisoning and subsequent psychiatric disorder is unknown. Aim : To examine the association between poisoning with paracetamol or other weak analgesics and subsequent psychiatric disorder. Methods : The study was set in a nested case-control design and based on nationwide Danish registers. We identified all patients diagnosed with schizophrenia, affective disorder or eating disorder in 1994-1998 and matched population controls. We estimated the relative risk of these psychiatric disorders after admission for paracetamol or nonparacetamol poisoning, adjusting for income, employment and marital status. Results : We included 12 603 cases with psychiatric disorder, and 1.2% had a diagnosis of poisoning compared with 0.2% of the 252 060 matched population controls. Compared with those with no diagnoses of weak analgesic poisoning, the risk of schizophrenia increased 3.9-fold after paracetamol poisoning, and 2.0-fold after nonparacetamol poisoning. The risk of affective disorder increased 12.2-fold after paracetamol poisoning and 2.6-fold after nonparacetamol poisoning. The risk of eating disorder increased 5.0-fold after paracetamol poisoning, and 2.2-fold after nonparacetamol poisoning. The risk of a diagnosis of psychiatric disorder was very high immediately after poisoning and remained increased for more than 10 years. Conclusions : Paracetamol poisoning is a strong risk marker for psychiatric disorder, particularly affective disorders.",
language="",
issn="0269-2813",
doi="10.1111/j.1365-2036.2005.02638.x",
url="http://dx.doi.org/10.1111/j.1365-2036.2005.02638.x"
}