@article{ref1,
title="A Comparison of Venlafaxine and SSRIs in Deliberate Self-poisoning",
journal="Journal of medical toxicology",
year="2010",
author="Chan, Agnes N. and Gunja, Naren and Ryan, Christopher J.",
volume="6",
number="2",
pages="116-121",
abstract="<p>To compare the clinical features of deliberate self-poisoning with venlafaxine and selective serotonin reuptake inhibitors (SSRIs) presenting to the emergency department of an Australian tertiary referral hospital. A retrospective cohort study comparing all 36 patients who presented with venlafaxine self-poisoning with 44 randomly selected patients with SSRI self-poisoning between 1997 and 2006. Patients who had overdosed on venlafaxine were older (mean age 37.4 versus 28.8 years, p </= 0.001) and generally exhibited a higher degree of suicidal intent (p </= 0.017). Median venlafaxine dose taken was 35 defined daily doses (DDDs) compared with SSRIs 19.4 DDDs. Those who ingested venlafaxine were more likely to become confused (25% versus 0%; p = 0) and have mydriasis (19.4% versus 2%; p </= 0.02), than those who took SSRIs. One patient from the venlafaxine group died. Compared with SSRI self-poisoners, patients who deliberately ingested venlafaxine were more likely to exhibit serious suicide intent. They were also more likely to be older, take a higher DDD of the drug, and have confusion and mydriasis. This has implications for management of severely depressed and suicidal patients.<p /> <p>Language: en</p>",
language="en",
issn="1556-9039",
doi="10.1007/s13181-010-0013-x",
url="http://dx.doi.org/10.1007/s13181-010-0013-x"
}