@article{ref1,
title="Pharmacokinetics of biological tags in a case of acute valpromide self poisoning",
journal="Annales de Biologie Clinique",
year="2010",
author="Commandeur, Diane and Danguy Des Deserts, Marc and Giacardi, Christophe and Eyrieux, Sandrine and Ould-Ahmed, Mehdi and Drouillard, Isabelle",
volume="68",
number="2",
pages="234-238",
abstract="We report the case of a 35-year-old woman hospitalized in intensive care unit after valpromide self-poisoning (Dépamide(R)). The dose supposed to be taken was 15 g. The patient eleven hours after ingestion, presented, a coma with bilateral non-reactive mydriasis, justifying intubation and mechanical ventilation. An acidosis (pH = 7.24), a hyperlactatemia (2.72 mmol/L), a hyperammonemia (328.9 mumol/L), and were diagnosed valproic acid plasmatic concentration was 1190 mug/mL at 22 hours. Symptomatic treatment and L-carnitine therapy (50 mg/kg/12h) normalized the action of biological abnormalities and allowed disappearance of symptoms; the patient was extubated after 46 hours, and outcome from intensive care unit at 65 hours.<p /> <p>Language: fr</p>",
language="fr",
issn="0003-3898",
doi="10.1684/abc.2010.0421",
url="http://dx.doi.org/10.1684/abc.2010.0421"
}