@article{ref1,
title="Malnutrition and inflammation in acute kidney injury due to earthquake-related crush syndrome",
journal="BMC nephrology",
year="2010",
author="Li, Guohua and Chen, Xiaoming and Zhang, Yunlong and He, Qinghua and Wang, Faming and Hong, Da-Qing and Zhang, Pengcheng and Pu, Lei and Zhang, Yunlong and Yang, Xiu-Chuan and Wang, Lili",
volume="11",
number="1",
pages="4-4",
abstract="BACKGROUND: Malnutrition and inflammation are common and serious complications in patients with acute kidney injury (AKI). However, the profile of these complications in patients with AKI caused by crush syndrome (CS) remains unclear. This study describes the clinical characteristics of malnutrition and inflammation in patients with AKI and CS due to the Wenchuan earthquake. METHODS: Nine-hundred and eighty-six victims were recruited to the study. They were divided into three groups: Group A was composed of victims without CS (904 cases); Group B was composed of CS patients without AKI (57 cases); and Group C was composed of CS patients with AKI (25 cases). A group of participants with AKI that was not caused by CS were recruited as the control group (26 cases). The C-reactive protein (CRP), prealbumin, transferrin, interleukin-6 and TNF-alpha were measured and compared between the groups. RESULTS: The results indicate that participants in Group C had the highest level of serum creatinine, blood urea nitrogen and uric acid. Approximately 92% of patients with CS who had received renal replacement therapy (RRT) were suffering from hypoalbuminemia. The interleukin-6 and CRP levels were significantly higher in CS patients with RRT, regardless of their group, than in the control group. Patients in Group C received the highest dosages of albumin, plasma or red blood cell transfusions. One patient in Group C died during treatment. CONCLUSIONS: Malnutrition and inflammation was common in patients with earthquake-related CS and had a negative impact on the prognosis of these subjects. The results of this study indicate that the use of RRT, intensive nutritional supplementation and transfusion alleviated the degree of malnutrition and inflammation in hemodialysis patients with crush syndrome.<p /> <p>Language: en</p>",
language="en",
issn="1471-2369",
doi="10.1186/1471-2369-11-4",
url="http://dx.doi.org/10.1186/1471-2369-11-4"
}