@article{ref1,
title="Early stress is associated with alterations in the orbitofrontal cortex: a tensor-based morphometry investigation of brain structure and behavioral risk",
journal="Journal of neuroscience",
year="2010",
author="Hanson, Jamie L. and Chung, Mina K. and Avants, Brian B. and Shirtcliff, Elizabeth A. and Gee, James C. and Davidson, R. J. and Pollak, Seth D.",
volume="30",
number="22",
pages="7466-7472",
abstract="Individuals who experience early adversity, such as child maltreatment, are at heightened risk for a broad array of social and health difficulties. However, little is known about how this behavioral risk is instantiated in the brain. Here we examine a neurobiological contribution to individual differences in human behavior using methodology appropriate for use with pediatric populations paired with an in-depth measure of social behavior. We show that alterations in the orbitofrontal cortex among individuals who experienced physical abuse are related to social difficulties. These data suggest a biological mechanism linking early social learning to later behavioral outcomes.<p /> <p>Language: en</p>",
language="en",
issn="0270-6474",
doi="10.1523/JNEUROSCI.0859-10.2010",
url="http://dx.doi.org/10.1523/JNEUROSCI.0859-10.2010"
}