@article{ref1,
title="Hypokalemia without arterial hypertension by licorice poisoning",
journal="Nephrologie",
year="1993",
author="Luchon, L. and Meyrier, A. and Paillard, F.",
volume="14",
number="4",
pages="177-181",
abstract="We report a case of chronic intoxication with glycyrrhizinic acid, at a dosage of 1000 to 1500 mg per month over a period of 11 months, in a former alcoholic. This intoxication was revealed by profound hypokalaemia and rhabdomyolysis. However, blood pressure remained constantly normal. Analysis of the literature shows that liquorice intoxication, which blocks renal 11 beta-hydroxysteroid dehydrogenase evolves more frequently as isolated hypokalaemia than as a picture of pseudo-primary hyperaldosteronism accompanied with hypertension. Hypokalaemia with urinary potassium wasting and without hypertension should therefore lead to considering liquorice intoxication, which can be confirmed by disclosing shut-off of the renin-angiotensin-aldosterone axis, and by the increase of the urinary ratio of cortisol metabolites (5 alpha tetrahydrocortisol + 5 beta tetrahydrocortisol)./cortisone metabolite (5 beta tetrahydrocortisol). together with increase of urinary free cortisol excretion.<p /><p>Language: fr</p>",
language="fr",
issn="0250-4960",
doi="",
url="http://dx.doi.org/"
}