@article{ref1,
title="The Overt Aggression Scale in a study of lithium in aggressive conduct disorder",
journal="Psychopharmacology bulletin",
year="1994",
author="Malone, R. P. and Luebbert, J. and Pena-Ariet, M. and Biesecker, K. and Delaney, M. A.",
volume="30",
number="2",
pages="215-218",
abstract="This article describes an open study of lithium carbonate in conduct-disordered children. The objective of the study was to investigate the effectiveness of lithium in reducing aggression and the usefulness of the Overt Aggression Scale (OAS), as a measure of treatment effect. The subjects, 8 children, ages 9.2 to 16.9 years (mean +/- standard deviation SD = 12.48 +/- 2.97), were treated for 4 weeks with lithium. Optimal dosages ranged from 1200 to 1800 mg/day (mean = 1350 +/- 227) with corresponding serum lithium levels ranging from 0.86 to 1.39 mEq/L (mean = 1.05 +/- 0.17). OAS results indicated that aggression decreased significantly over time. The findings from the OAS agreed with findings from a more general measure, the Global Clinical Consensus Rating, leading to the conclusion that the OAS is a promising outcome measure for treatment studies of aggression in children. Further placebo-controlled studies of lithium carbonate in reducing aggressive behavior in conduct-disordered children, employing a specific measure such as the OAS, are warranted.<p /><p>Language: en</p>",
language="en",
issn="0048-5764",
doi="",
url="http://dx.doi.org/"
}