@article{ref1,
title="Influence of antemortem medication on the determination of brain death",
journal="Nippon Hoigaku Zasshi",
year="1995",
author="Saito, T. and Takeichi, S. and Nakajima, Y. and Yukawa, Nobuhiro and Osawa, M.",
volume="49",
number="6",
pages="484-487",
abstract="Post-mortem concentration of pentobarbital in the blood and brain of two deceased neurosurgical patients was determined by gas chromatography/mass spectrometry. Patients treated with barbiturate for elevated intracranial pressure after head injury may incur brain death. In the present two cases of brain death a large amount of barbiturate remained in the brain, even when the blood concentration was not detectable, possibly because the blood flow was stagnant in the brain. It is suggested that a patient under barbiturate coma should be given serious consideration as to the determination of brain death, even if barbiturate is negative in the blood.<p /><p>Language: en</p>",
language="en",
issn="0047-1887",
doi="",
url="http://dx.doi.org/"
}