@article{ref1,
title="Effect of acute paracetamol overdose on changes in serum and urine electrolytes",
journal="British journal of clinical pharmacology",
year="2007",
author="Pakravan, N. and Bateman, D. Nicholas and Goddard, J.",
volume="64",
number="6",
pages="824-832",
abstract="AIMS: To investigate the effects of acute paracetamol overdose on renal function, serum and urine electrolyte excretion in man. METHODS: Two studies were performed in patients admitted with paracetamol overdose: a retrospective study examining changes in serum electrolytes, and a prospective study evaluating changes in serum and urine electrolytes. A control group with SSRI overdose was included in the prospective study. RESULTS: There was a significant dose-dependent relationship between admission (4 h) paracetamol concentration and fall in serum potassium in the retrospective study (P < 0.01) and a significant positive relationship between serum paracetamol at 4 h and fractional excretion of potassium at 12 h postingestion (P < 0.01) in the prospective study. No changes were seen in the control group. No cases developed renal failure. CONCLUSIONS: Paracetamol overdose is associated with dose-related hypokalaemia, and kaliuresis of short duration (<24 h), suggesting a specific renal effect of paracetamol in overdose perhaps via cyclo-oxygenase inhibition. This effect seems distinct from any nephrotoxic effect of paracetamol.<p /><p>Language: en</p>",
language="en",
issn="0306-5251",
doi="10.1111/j.1365-2125.2007.02952.x",
url="http://dx.doi.org/10.1111/j.1365-2125.2007.02952.x"
}