@article{ref1,
title="Amyotrophic lateral sclerosis, heterogeneous susceptibility, trauma, and epidemiology",
journal="Archives of neurology",
year="1996",
author="Riggs, J. E.",
volume="53",
number="3",
pages="225-227",
abstract="Epidemiological studies relating antecedent trauma and amyotrophic lateral sclerosis (ALS) demonstrate a contradiction: positive (but poorly structured) retrospective case-control studies and negative (but uninterpretably small) prospective cohort studies. In this report, the equations for the case-control odds ratio and cohort relative risk in populations with heterogeneous susceptibility to ALS are analyzed. The case-control odds ratio and cohort relative risk converge as the proportion of ALS-nonsusceptible individuals in a population increases and the rate of ALS in nonsusceptible individuals decreases. Cohort studies of antecedent trauma and ALS have no significant advantage over case-control studies in populations in which most individuals are relatively nonsusceptible to ALS. Accordingly, the relationship between antecedent trauma and ALS can be addressed by carefully defined case-control studies.<p /><p>Language: en</p>",
language="en",
issn="0003-9942",
doi="",
url="http://dx.doi.org/"
}