@article{ref1,
title="Serotonin function in human subjects: intercorrelations among central 5-HT indices and aggressiveness",
journal="Psychiatry research",
year="1997",
author="Coccaro, E. F. and Kavoussi, R. J. and Trestman, R. L. and Gabriel, S. M. and Cooper, T. B. and Siever, Larry J.",
volume="73",
number="1-2",
pages="1-14",
abstract="Three central indices of serotonin (5-HT) system activity in human subjects were examined to: (a) estimate intercorrelations among 5-HT indices and (b) compare correlations of these indices with a measure of assaultiveness (Buss-Durkee 'Assault') in personality-disordered individuals. Cerebrospinal fluid (CSF) 5-hydroxyindoleacetic acid (5-HIAA) concentration and prolactin responses to m-chlorophenylpiperazine (m-CPP) m-CPP (PRL[m-CPP]) and fenfluramine (PRL[FEN]), served as indices of pre-, post- and 'net'-synaptic central 5-HT activity, respectively. PRL[D,L-FEN] responses were inversely related to CSF 5-HIAA concentration and positively correlated with PRL[m-CPP] responses. Both PRL[D,L-FEN] and PRL[m-CPP] response data correlated equally, and inversely, with BD Buss-Durkee Assault when the same subjects were examined. Basal CSF 5-HIAA concentration did not correlate with Buss-Durkee 'Assault'. PRL responses to challenge probes which involve activation of 5-HT post-synaptic receptors may correlate better than a basal measure of pre-synaptic 5-HT function with a tendency to assaultive behavior in non-criminally aggressive personality-disordered individuals.<p /><p>Language: en</p>",
language="en",
issn="0165-1781",
doi="",
url="http://dx.doi.org/"
}