@article{ref1,
title="Suicidal attempts and increased right amygdala volume in schizophrenia",
journal="Schizophrenia Research",
year="2011",
author="Spoletini, Ilaria and Piras, Fabrizio and Fagioli, Sabrina and Rubino, I. A. and Martinotti, G. and Siracusano, A. and Caltagirone, Carlo and Spalletta, Gianfranco",
volume="125",
number="1",
pages="30-40",
abstract="Suicide is a major cause of death in schizophrenia. Neurobiological studies suggest that suicidality is associated with abnormal brain structure and connectivity in fronto-temporo-limbic regions. However, it is still unclear whether suicidality in schizophrenia is related to volumetric abnormalities in subcortical structures that play a key role in emotion regulation, aggression and impulse control. Therefore, we aimed to examine whether the volume of selected subcortical regions is associated with previous suicidal attempts and self-aggression in schizophrenia. For this cross-sectional study, we recruited 50 outpatients with schizophrenia and 50 healthy controls (HC) matched for age and gender. Fourteen patients had a history of one or more suicide attempts. Different forms of aggression were assessed using the Modified Overt Aggression Scale. All participants underwent structural MR imaging at 3 Tesla. Physical volumetric measures were calculated for the lateral ventricles, thalamus, hippocampus, amygdala, caudate, putamen, pallidum and accumbens using an automatic segmentation method on T1-weighted high-resolution (voxel size 1×1×1mm(3)) images. Multivariate and follow-up univariate ANOVAs revealed a selective increase in volume in the right amygdala of patients with a history of suicidality compared both to patients without such a history and HC. Moreover, in the entire patient group increased right amygdala volume was related to increased self-aggression. Our findings suggest that right amygdala hypertrophy may be a risk factor for suicide attempts in patients with schizophrenia and this could be relevant for suicide prevention.<p /> <p>Language: en</p>",
language="en",
issn="0920-9964",
doi="10.1016/j.schres.2010.08.023",
url="http://dx.doi.org/10.1016/j.schres.2010.08.023"
}