@article{ref1,
title="Aggression, hostility, and irritability in children at risk for bipolar disorder",
journal="Bipolar disorders",
year="2007",
author="Farchione, Tiffany R. and Birmaher, B. and Axelson, David A. and Kalas, Cathy and Monk, Kelly and Ehmann, Mary and Iyengar, Satish and Kupfer, David and Brent, David A.",
volume="9",
number="5",
pages="496-503",
abstract="OBJECTIVES: To assess aggression, irritability and hostility in children at risk for bipolar disorder (BP). METHODS: Using the parent and the child versions of the Children's Hostility Inventory (CHI), we assessed aggression, hostility, and irritability in 300 offspring aged 6-18 years old of BP parents and 169 children of community controls. RESULTS: Children of BP parents have significantly higher scores on the total CHI and its subscales than do children of control parents. After adjusting for demographic variables, both parents' non-BP psychopathology, child psychopathology, and within-family correlations, three factors remain significant: total CHI by parent rating, irritability subscale by parent rating, and irritability by child self-report. The hostility subscale by parent rating became a trend. CONCLUSIONS: Children of BP parents score higher on ratings of hostility and irritability than children of community control parents, independent of child psychopathology and non-BP parental psychopathology. Follow-up of these children to evaluate whether these symptoms are markers for the development of BP or mood disorders is warranted.<p /><p>Language: en</p>",
language="en",
issn="1398-5647",
doi="10.1111/j.1399-5618.2007.00390.x",
url="http://dx.doi.org/10.1111/j.1399-5618.2007.00390.x"
}