@article{ref1,
title="Pharmacological management of aggression and violence",
journal="Human psychopharmacology",
year="2003",
author="Humble, F. and Berk, M.",
volume="18",
number="6",
pages="423-436",
abstract="The pharmacological management of violence and aggression is a common and substantial clinical dilemma in the emergency psychiatric situation. A literature search was conducted through PubMed and using the Cochrane Library. This was followed by a manual search of selected literature. Randomised controlled trials were sought that specifically addressed the acute situation, rather than the ongoing management of chronic conditions. There was a paucity of well-controlled data and insufficient evidence to support the use of many agents in emergency situations. Many studies had considerable limitations making comparison difficult. Efficacy data for a range of treatment options exists, including the use of classical and atypical anti-psychotic agents, benzodiazepines and combination therapies. Clinical risk, tolerability and environmental factors need to form part of a careful and considered judgement in the choice of treatment. Safety, tolerability and the potential for a positive experience are major considerations, thus paving the way for long term compliance.<p /><p>Language: en</p>",
language="en",
issn="0885-6222",
doi="10.1002/hup.504",
url="http://dx.doi.org/10.1002/hup.504"
}