@article{ref1,
title="Engineered chloroplasts as vaccine factories to combat bioterrorism",
journal="Trends in biotechnology",
year="2006",
author="Streatfield, Stephen J.",
volume="24",
number="8",
pages="339-342",
abstract="Bacillus anthracis is ideal for making biological weapons, but the licensed anthrax vaccine is unsuitable for widespread public administration. Recombinant subunit-vaccine candidates offer potential alternatives, and plant-based production systems facilitate the inexpensive bulking of target antigens. A recent report demonstrates expression of anthrax protective antigen in tobacco chloroplasts--this material is immunogenic and protective when injected into mice. Provided an economic purification scheme can be developed, this technology holds promise for an improved vaccine.<p /><p>Language: en</p>",
language="en",
issn="0167-7799",
doi="10.1016/j.tibtech.2006.06.006",
url="http://dx.doi.org/10.1016/j.tibtech.2006.06.006"
}