@article{ref1,
title="Anxiolytics' effects on the actual driving performance of patients and healthy volunteers in a standardized test. An integration of three studies",
journal="Neuropsychobiology",
year="1995",
author="O'Hanlon, J. F. and Vermeeren, A. and Uiterwijk, M. M. and van Veggel, L. M. and Swijgman, H. F.",
volume="31",
number="2",
pages="81-88",
abstract="Effects of benzodiazepine (diazepam, lorazepam) and benzodiazepine-like anxiolytics (alpidem, suriclone) and a 5-HT-3 antagonist (ondansetron) on actual driving performance were measured in three double-blind, placebo-controlled studies. Subjects were healthy volunteers in two and anxious patients in the third. Treatments lasted for 8 days. Standardized testing occurred within the first full day and on the last day of treatment. No important differences existed between volunteers' and patients' baseline and/or placebo performances and both groups responded similarly to comparable drugs/doses. Benzodiazepine and benzodiazepine-like anxiolytics produced marked and pervasive driving impairment, which lasted throughout treatment; but ondansetron, none.<p /><p>Language: en</p>",
language="en",
issn="0302-282X",
doi="",
url="http://dx.doi.org/"
}