@article{ref1,
title="Profile of acute tolerance to three sedative anxiolytics",
journal="Psychopharmacology",
year="1983",
author="Ellinwood, Everett H. and Linnoila, M. and Easler, M. E. and Molter, D. W.",
volume="79",
number="2-3",
pages="137-141",
abstract="Acute tolerance, defined as a decreasing drug effect relative to drug-plasma levels (DPL) over a period of minutes to a few hours, is pronounced following single doses of diazepam or pentobarbital. Both of these lipid-soluble drugs produce an early peak behavioral impairment and subsequent rapid recovery component that is followed by a much slower blood-drug rise time. These pronounced early peak effects were not shared by alcohol, and contribute significantly to the lack of correlation between impairment and DPL.<p /><p>Language: en</p>",
language="en",
issn="0033-3158",
doi="",
url="http://dx.doi.org/"
}