@article{ref1,
title="Abnormal behavior associated with a point mutation in the structural gene for monoamine oxidase A",
journal="Science",
year="1993",
author="Brunner, H. G. and Nelen, M. and Breakefield, X. O. and Ropers, Hans-Hilger and van Oost, B. A.",
volume="262",
number="5133",
pages="578-580",
abstract="Genetic and metabolic studies have been done on a large kindred in which several males are affected by a syndrome of borderline mental retardation and abnormal behavior. The types of behavior that occurred include impulsive aggression, arson, attempted rape, and exhibitionism. Analysis of 24-hour urine samples indicated markedly disturbed monoamine metabolism. This syndrome was associated with a complete and selective deficiency of enzymatic activity of monoamine oxidase A (MAOA). In each of five affected males, a point mutation was identified in the eighth exon of the MAOA structural gene, which changes a glutamine to a termination codon. Thus, isolated complete MAOA deficiency in this family is associated with a recognizable behavioral phenotype that includes disturbed regulation of impulsive aggression.<p /><p>Language: en</p>",
language="en",
issn="0036-8075",
doi="",
url="http://dx.doi.org/"
}