@article{ref1,
title="Wound Healing after Trauma may Predispose to Lung Cancer Metastasis: Review of Potential Mechanisms",
journal="American journal of respiratory cell and molecular biology",
year="2011",
author="Walter, Nicholas D. and Rice, Pamela L. and Redente, Elizabeth F. and Kauvar, Emily F. and Lemond, Lisa and Aly, Theresa and Wanebo, Kevin and Chan, Edward D.",
volume="44",
number="5",
pages="591-596",
abstract="Inflammatory oncotaxis, where mechanically injured tissues are predisposed to cancer metastases, has been reported for a number of tumor types but not previously for lung cancer. We review clinical and experimental evidence, mechanisms that may underlie inflammatory oncotaxis, and provide illustrative examples of two patients with squamous cell carcinoma of the lung who developed distant, localized metastatic disease at sites of recent physical trauma. Trauma may predispose to metastasis through two distinct but not mutually exclusive mechanisms: 1) physical trauma induces tissue damage and local inflammation, creating a favorable environment that is permissive for seeding of metastatic cells from distant sites and/or 2) micro-metastatic foci are already present at the time of physical injury and trauma initiates changes in the micro-environment that stimulate the proliferation of the metastatic cells.<p /> <p>Language: en</p>",
language="en",
issn="1044-1549",
doi="10.1165/rcmb.2010-0187RT",
url="http://dx.doi.org/10.1165/rcmb.2010-0187RT"
}