@article{ref1,
title="Interferon beta-1a-induced depression and suicidal ideation in multiple sclerosis",
journal="Arquivos de Neuro-Psiquiatria",
year="2002",
author="Lana-Peixoto, Marco Aurélio and Teixeira, Antonio Lucio and Haase, Vitor Geraldi",
volume="60",
number="3-B",
pages="721-724",
abstract="Depression and suicide have been reported in association with multiple sclerosis (MS). Some studies show that interferon beta may increase the depression rate. We report a case of depression and suicidal ideation in coincidence with the start of increased doses of interferon beta-1a and their complete reversal following the drug withdrawal. The patient was a 21-year-old man with MS and no past history of affective disorders who was given interferon beta-1a in the dose of 11 microgram three times per week. As a new relapse occurred the dose of interferon beta-1a was increased to 22 microgram three times a week. The patient then observed increased worry, irritability and a sense of discouragement as well as recurring suicidal thoughts. His mood was rapidly restored following interferon beta-1a withdrawal. This case suggests that patients with MS may develop depression and suicidal thoughts when treated with high doses of interferon beta-1a.<p /><p>Language: en</p>",
language="en",
issn="0004-282X",
doi="",
url="http://dx.doi.org/"
}