@article{ref1,
title="Risperidone in the treatment of acute mania: double-blind, placebo-controlled study",
journal="British journal of psychiatry",
year="2005",
author="Khanna, Sumant and Vieta, Eduard and Lyons, Benjamin and Grossman, Fred and Eerdekens, Mariëlle and Kramer, Michelle",
volume="187",
number="",
pages="229-234",
abstract="BACKGROUND: Severe mania is life-threatening, carries an increased risk of suicide and has a serious impact on patients and their families. Efficient and rapid control of episodes of acute mania is needed. AIMS: To evaluate the safety and efficacy of risperidone monotherapy for acute mania. METHOD: In a 3-week, randomised, double-blind trial, 290 in-patients with bipolar I disorder with current manic or mixed episode and a baseline Young Mania Rating Scale (YMRS) score of 20 or more received flexible doses of risperidone (1-6 mg per day) or placebo. RESULTS: Risperidone was received by 146 patients and placebo by144. Their mean baseline YMRS score was 37.2 (s.e.=0.5). Significantly greater improvements were observed with risperidone than with placebo at weeks 1 and 2 and at end-point (total YMRS: P <0.01). Extrapyramidal symptoms were the most frequently reported adverse events in the risperidone group. CONCLUSIONS: In patients with severe manic symptoms, risperidone produced significant improvements in YMRS scores as early as week 1 and substantial changes at end-point. Treatment was well tolerated.<p /><p>Language: en</p>",
language="en",
issn="0007-1250",
doi="10.1192/bjp.187.3.229",
url="http://dx.doi.org/10.1192/bjp.187.3.229"
}