@article{ref1,
title="Active monitoring of 12,760 clozapine recipients in the UK and Ireland. Beyond pharmacovigilance",
journal="British journal of psychiatry",
year="1999",
author="Munro, J. and O'Sullivan, D. and Andrews, C. and Arana, A. and Mortimer, A. and Kerwin, R.",
volume="175",
number="",
pages="576-580",
abstract="BACKGROUND: People prescribed clozapine for treatment-resistant schizophrenia have mandatory haematological monitoring through a case register for identifying reversible neutropenia. AIMS: To quantify risk factors for agranulocytosis in subjects receiving clozapine. METHOD: Data from 12,760 subjects registered to receive clozapine from January 1990 to April 1997 were analysed. Risk factors for agranulocytosis were quantified using a Cox proportional-hazards regression analysis. RESULTS: The risk for agranulocytosis in Asian subjects was 2.4 times that in Caucasians (P = 0.03). There was an age-related increase in risk of 53% per decade (P = 0.0001). CONCLUSIONS: The case register yielded valuable information for guiding research into the causes of the haematological reactions.<p /><p>Language: en</p>",
language="en",
issn="0007-1250",
doi="",
url="http://dx.doi.org/"
}