@article{ref1,
title="Determination of metaldehyde in human serum by headspace solid-phase microextraction and gas chromatography-mass spectrometry",
journal="Journal of chromatography B: analytical technologies in the biomedical and life sciences",
year="2008",
author="Saito, Takeshi and Morita, Seiji and Motojyuku, Megumi and Akieda, Kazuki and Otsuka, Hiroyuki and Yamamoto, Isotoshi and Inokuchi, Sadaki",
volume="875",
number="2",
pages="573-576",
abstract="A rapid headspace solid-phase microextraction-gas chromatography-mass spectrometry (HS-SPME-GC-MS) method has been developed for the determination of metaldehyde in human serum samples. Metaldehyde is extensively used as a molluscicide for the control of slugs and snails, and cases of metaldehyde poisoning have been reported. Metaldehyde was headspace-extracted on a polydimethylsiloxane (PDMS) fiber at 70 degrees C for 25 min, desorbed, and analyzed rapidly by GC-MS. The method was validated for limit of detection (LOD), linearity, precision, and recovery. Although the recovery of the sample was very low, the method itself was rapid with a low detection limit of 0.25 microg/ml, R.S.D. value 12.6%, and linearity range 0.5-25.0 microg/ml (r(2)=0.999). The results demonstrated that the SPME-GC-MS method for the analysis of metaldehyde is simple, rapid, solvent-free, and does not require any pre-analysis conversions.<p /><p>Language: en</p>",
language="en",
issn="1570-0232",
doi="10.1016/j.jchromb.2008.10.002",
url="http://dx.doi.org/10.1016/j.jchromb.2008.10.002"
}