@article{ref1,
title="Hydroxychloroquine overdose: toxicokinetics and management",
journal="Journal of toxicology - clinical toxicology",
year="1999",
author="Jordan, P. and Brookes, J. G. and Nikolic, G. and Le Couteur, David G.",
volume="37",
number="7",
pages="861-864",
abstract="BACKGROUND: The management and toxicokinetics of hydroxychloroquine overdose are poorly described. CASE REPORT: We report a case of an 18-year-old girl who ingested 20 g of hydroxychloroquine. She developed marked hypokalemia, hypotension, and ventricular tachyarrhythmias but survived with treatment including intubation, adrenaline infusion, high-dose diazepam, and aggressive potassium replacement. Plasma hydroxychloroquine level was 29.40 mumol/L (9.87 mg/L) 2 hours after ingestion and the elimination half-life of hydroxychloroquine was 22 hours. CONCLUSIONS: The clinical manifestations of this hydroxychloroquine overdose were similar to those reported for chloroquine overdose and the management principles recommended for chloroquine overdose appeared to be efficacious in this case.<p /><p>Language: en</p>",
language="en",
issn="0731-3810",
doi="",
url="http://dx.doi.org/"
}