@article{ref1,
title="Protein kinase C in the postmortem brain of teenage suicide victims",
journal="Neuroscience letters",
year="1997",
author="Pandey, Ganshayam N. and Dwivedi, Y. and Pandey, S. C. and Conley, R. R. and Roberts, R. C. and Tamminga, C. A.",
volume="228",
number="2",
pages="111-114",
abstract="Increased serotonin2A (5-HT2A) receptors have been reported in the postmortem brain of suicide victims. To examine if this increase is associated with the dysregulation of postreceptor sites in the signaling cascade, we determined [3H]phorbol dibutyrate (PDBU) binding to protein kinase C (PKC) in postmortem brain samples (Brodmann's areas 8 and 9) obtained from teenage suicide victims and control subjects. [3H]PDBU binding to PKC was determined in membranal and cytosolic fractions. We observed that Bmax of [3H]PDBU binding sites was significantly decreased in both membranal and cytosolic fractions in brain samples from Brodmann's areas 8-9 compared to matched controls. These results thus suggest that PKC may play a role in the pathophysiology of suicidal behavior.<p /><p>Language: en</p>",
language="en",
issn="0304-3940",
doi="",
url="http://dx.doi.org/"
}