@article{ref1,
title="SCN8A as a novel candidate gene associated with bipolar disorder in the Han Chinese population",
journal="Progress in neuro-psychopharmacology and biological psychiatry",
year="2008",
author="Wang, Yang and Zhang, Jing and Li, Xingwang and Ji, Jue and Yang, Fengping and Wan, Chunling and Feng, Guoyin and Wan, Peng and He, Lin and He, Guang",
volume="32",
number="8",
pages="1902-1904",
abstract="BACKGROUND: Bipolar disorder (BPD) is a common, severe and recurrent psychiatric disorder. It has been suggested that BPD patients have a higher risk of suicide than patients with any other psychiatric illnesses. A recent study found that suicide attempt was associated with the SCN8A gene, which has been mapped close to one of the BPD susceptibility loci. Thus, SCN8A is likely to be a candidate gene for BPD. METHODS: In this study, three SNPs (rs1601012, rs303810, rs60637) were analyzed in 506 bipolar patients and 507 controls of Han origin. RESULTS: We found that two individual SNPs showed statistically significant differences between cases and controls in both allele and genotype distribution, but only rs303810 was still significant in allele distribution (p=0.0164) after correction. No obvious linkage disequilibrium or haplotypes were observed among these SNPs. CONCLUSION: Our results indicate that SCN8A may be a potential susceptibility gene for bipolar disorder in the Han Chinese population.<p /><p>Language: en</p>",
language="en",
issn="0278-5846",
doi="10.1016/j.pnpbp.2008.09.003",
url="http://dx.doi.org/10.1016/j.pnpbp.2008.09.003"
}