@article{ref1,
title="Platelet serotonin and [3H]paroxetine binding correlate with recurrence of suicidal behavior",
journal="Psychopharmacology",
year="1997",
author="Verkes, Robbert-Jan and Fekkes, D. and Zwinderman, Aeilko H. and Hengeveld, M. W. and Van der Mast, R. C. and Tuyl, J. P. and Kerkhof, A. J. and Van Kempen, G. M.",
volume="132",
number="1",
pages="89-94",
abstract="To distinguish state- from trait-dependent associations between serotonergic function and suicidal behavior, platelet serotonergic measures were repeatedly measured, during a 1-year follow-up, in 106 patients who had recently attempted suicide for at least a second time. A major DSM-III-R axis I diagnosis or use of antidepressants were reasons for exclusion. A higher affinity constant (KD) of platelet [3H]paroxetine binding was related to a higher risk of short-term recurrence of a suicide attempt, suggesting a state relationship. Higher levels of platelet serotonin at baseline were a significant predictor of a recurrent suicide attempt within the year of follow-up, suggesting a trait relationship. These associations held equally within the subgroup of 73 patients with a borderline personality disorder. Neither the maximum number of binding sites (Bmax) of [3H]paroxetine nor platelet monoamine oxidase activity correlated with suicidality. The observed association between indicators of platelet serotonin uptake and suicidal behavior suggests a state- and trait-dependency between suicidality and central serotonergic dysfunction.<p /><p>Language: en</p>",
language="en",
issn="0033-3158",
doi="",
url="http://dx.doi.org/"
}