@article{ref1,
title="Prolonged anticoagulation following chlorophacinone poisoning",
journal="Schweizerische Medizinische Wochenschrift",
year="1988",
author="Vogel, J. J. and de Moerloose, P. and Bouvier, C. A. and Gaspoz, J. and Riant, P.",
volume="118",
number="50",
pages="1915-1917",
abstract="In 1985 and 1986 the Swiss Toxicologic Information Center registered 152 cases of rodenticide poisoning. Among those substances chlorophacinone, an indanedione derivative, has a prolonged antivitamin K effect. We report here the case of an eighteen-year-old female hospitalized 3 days after deliberately ingesting some 100 mg chlorophacinone. Her Quick time at admission was less than 10% (Prothrombin time 79 sec., normal control 12 sec.). Under high dose vitamin K therapy the Quick was rapidly corrected but fell again on each vitamin K withdrawal. In a search for a relation between the variations of prothrombin time and chlorophacinone plasma levels, these were assessed by HPLC. Prothrombin time (and vitamin K dependent factors VII and X) finally normalized only 7 weeks after chlorophacinone ingestion. Clinical condition remained satisfactory throughout and other biological parameters unaffected. This case emphasizes the need for prolonged clinical and laboratory follow-up for rodenticide intoxications and for vitamin K administration for several weeks.<p /><p>Language: fr</p>",
language="fr",
issn="0036-7672",
doi="",
url="http://dx.doi.org/"
}