@article{ref1,
title="2,3,7,8-Tetrachlorodibenzo-p-dioxin kills immature thymocytes by Ca2+-mediated endonuclease activation",
journal="Science",
year="1988",
author="McConkey, D. J. and Hartzell, P. and Duddy, S. K. and Håkansson, H. and Orrenius, S.",
volume="242",
number="4876",
pages="256-259",
abstract="Suspensions of thymocytes from young rats were incubated with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), which resulted in a sustained increase in cytosolic free Ca2+ concentration followed by DNA fragmentation and loss of cell viability. Both the Ca2+ increase and DNA fragmentation were prevented in cells treated with the inhibitor of protein synthesis, cycloheximide, and DNA fragmentation and cell killing were not detected when cells were incubated in a &quot;Ca2+-free&quot; medium or pretreated with high concentrations of the calcium probe, quin-2 tetraacetoxymethyl ester. These results indicate that TCDD can kill immature thymocytes by initiating a suicide process similar to that previously described for glucocorticoid hormones.<p /><p>Language: en</p>",
language="en",
issn="0036-8075",
doi="",
url="http://dx.doi.org/"
}